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902535

Sigma-Aldrich

Amino-PEG4-t-butyl ester

Synonym(s):

tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H2N-PEG4-CH2CH2COOtBu, H2N-dPEG(4)-CO-OtBu

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About This Item

Empirical Formula (Hill Notation):
C15H31NO6
CAS Number:
581065-95-4
Molecular Weight:
321.41
MDL number:
MFCD11041116
UNSPSC Code:
51171641
NACRES:
NA.22

form

liquid

reaction suitability

reagent type: cross-linking reagent

refractive index

n/D 1.4508

density

1.04479 g/mL

functional group

amine
ester

storage temp.

−20°C

SMILES string

NCCOCCOCCOCCOCCC(OC(C)(C)C)=O

InChI

1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3

InChI key

PKESARRNSGIDRD-UHFFFAOYSA-N

Related Categories

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Other Notes

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Development of Substrate-Selective Probes for Affinity Pulldown of Histone Demethylases

A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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