929476
N-Acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine
≥95%
Synonym(s):
p-Fluorobenzylguanine ligand, AUTAC ligand, FBnG
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About This Item
Empirical Formula (Hill Notation):
C17H17FN6O4S
CAS Number:
Molecular Weight:
420.42
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.21
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Quality Level
assay
≥95%
form
powder or chunks
reaction suitability
reagent type: ligand
storage temp.
2-8°C
SMILES string
O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(O)=O)NC(C)=O)N2CC3=CC=C(C=C3)F
Related Categories
Application
N-acetyl-S-(2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)-L-cysteine is a p-fluorobenzylguanine (FBnG) based ligand used to initiate selective autophagy as a strategy for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
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Other Notes
AUTACs: Cargo-Specific Degraders Using Selective Autophagy
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
related product
Product No.
Description
Pricing
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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William Farnaby et al.
Nature chemical biology, 15(7), 672-680 (2019-06-11)
Targeting subunits of BAF/PBAF chromatin remodeling complexes has been proposed as an approach to exploit cancer vulnerabilities. Here, we develop proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 and SMARCA4 using a bromodomain ligand and recruitment of
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