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1.06049

SAFC

Dichloromethane

EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

Pharma Manufacturing

Synonym(s):

DCM, Methylene chloride, Methylene dichloride, Methylene chloride

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About This Item

Empirical Formula (Hill Notation):
CH2Cl2
CAS Number:
75-09-2
Molecular Weight:
84.93
Beilstein/REAXYS Number:
1730800
MDL number:
MFCD00000881
UNSPSC Code:
12191502
EC Index Number:
200-838-9

agency

BP
NF
Ph. Eur.

Quality Level

500

vapor density

2.9 (vs air)

vapor pressure

24.45 psi ( 55 °C)
6.83 psi ( 20 °C)

product line

EMPROVE® ESSENTIAL

assay

≥99% (GC)

form

liquid

autoignition temp.

1223 °F
605 °C (DIN 51794)

expl. lim.

22 %

technique(s)

API processing | polymorph screening: suitable

refractive index

n20/D 1.424 (lit.)

pH

7 (20 °C)

bp

39.8-40 °C (lit.)

mp

-95 °C
−95 °C (lit.)

solubility

20 g/L

density

1.325 g/mL at 25 °C (lit.)

application(s)

liquid formulation
pharmaceutical

storage temp.

2-30°C

SMILES string

ClCCl

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChI key

YMWUJEATGCHHMB-UHFFFAOYSA-N

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Methanol is used as solvent in a variety of pharmaceutical production processes, including tablet coating, liposome production, microsphere, and nanoparticle production.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

wgk_germany

WGK 2

flash_point_f

does not flash

flash_point_c

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dichloromethane suitable for HPLC, ≥99.8%, contains amylene as stabilizer

Sigma-Aldrich

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Sigma-Aldrich

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Diethyl ether EMPROVE® ESSENTIAL, Ph. Eur., BP

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Sigma-Aldrich

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