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210150

Sigma-Aldrich

Cantharidic Acid

A potent inhibitor of protein phosphatase 2A (IC₅₀ = 50 nM).

Synonym(s):

Cantharidic Acid, 5ʹ-3ʹ2,3-Dicarboxy-2,3-dimethyl-1,4-epoxycyclohexane, exo-1,6-Dicarboxy- endo-1,6-dimethyl-7-oxabicylco[2,2,1]heptane

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About This Item

Empirical Formula (Hill Notation):
C10H14O5
CAS Number:
28874-45-5
Molecular Weight:
214.22
MDL number:
MFCD00047137
UNSPSC Code:
12352106
NACRES:
NA.77

Quality Level

100

assay

>95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

warm ethanol: 10 mg/mL
DMSO: 25 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9-,10+

InChI key

NMTNUQBORQILRK-YUMGAWCOSA-N

General description

A potent inhibitor of protein phosphatase 2A (IC50 = 50 nM).
Inhibits protein phosphatase 2A (IC50 = 50 nM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
PP2A
Product does not compete with ATP.
Reversible: no
Target IC50: 50 nM against protein phosphatase 2A

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliqot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhang, Z., et al. 1996. Biochemistry35, 1606.
Li, Y.-M., and Casida, J.E. 1992. Proc. Natl. Acad. Sci. USA89, 11867.
Graziano, M.J., et al. 1988. Mol. Pharmacol.33, 706.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 3

Certificates of Analysis (COA)

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