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Sigma-Aldrich

Nystatin, Streptomyces noursei

A polyene antifungal antibiotic effective against yeast and mycoplasma.

Synonym(s):

Nystatin, Streptomyces noursei, Mycostatin

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About This Item

Empirical Formula (Hill Notation):
C47H75NO17
CAS Number:
1400-61-9
Molecular Weight:
926.09
MDL number:
MFCD25541651
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥95% (sum of two peaks, HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white to yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1

InChI key

VQOXZBDYSJBXMA-RKEBNKJGSA-N

General description

A polyene antifungal antibiotic effective against yeast and mycoplasma. Induces loss of low molecular weight substances from cells with low selectivity. A cation selective ionophore that exhibits selectivity for Na+. Increases the activity of the Na+-K+ pump. Suggested concentration is 50 µg/ml.
A polyene antifungal antibiotic effective against yeast and mycoplasma. Induces loss of low molecular weight substances from cells with low selectivity. A cation-selective ionophore that exhibits selectivity for Na+. Increases the activity of Na+ - K+ pump.

Biochem/physiol Actions

Potency: ≥3000 units/mg (anhydrous).

Warning

Toxicity: Standard Handling (A)

Other Notes

Gruwel, M.L., et al. 1995. Am J. Physiol.268, H351.
Opekarova, M., and Tanner, W. 1994. FEBS Lett. 360, 46.
Stoos, B.A., et al. 1994. J. Am. Soc. Nephrol.4, 1855.
Skolink, P.R., et al. 1989. J. Infect. Dis.160, 1056.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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