5.06046
PRMT Inhibitor VII, DB867
Synonym(s):
PRMT Inhibitor VII, DB867, 5-[5-(4-Carbamimidoyl-phenyl)-furan-2-yl]-pyridine-2-carboxamidine
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About This Item
Empirical Formula (Hill Notation):
C17H15NO5
CAS Number:
Molecular Weight:
313.30
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
assay
≥98% (HPLC)
Quality Level
form
solid
potency
9 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
10% acetic acid: 5 mg/mL
storage temp.
2-8°C
General description
A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.
A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Primary Target
PRMT1
PRMT1
Reversible: yes
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Xu, J., et al, 2013. Mol. Cell.51, 1.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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