Telomerase Inhibitor X, BIBR1532

A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC₅₀ = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC₅₀ = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Cell permeable: yes

Primary Target
Teomerase

Reversible: yes

Packaged under inert gas

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Damm, K., et al. 2001. The. EMBO J.20, 6958.
Pascolo, E., et al. 2002. J. Biol. Chem.277,15566.

Nakashima, M., et al. 2013. J. Biol. Chem.288, 33171.

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