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581011

Sigma-Aldrich

Telomerase Inhibitor IX

The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

Telomerase Inhibitor IX, MST-312, N,Nʹ-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine

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About This Item

Empirical Formula (Hill Notation):
C20H16N2O6
CAS Number:
368449-04-1
Molecular Weight:
380.35
MDL number:
MFCD24368986
UNSPSC Code:
12352200
NACRES:
NA.54

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)

InChI key

MIQUEZGHEJGPJB-UHFFFAOYSA-N

General description

A cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 µM).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
TRAP lysate prepared from U937 cells
Product does not compete with ATP.
Reversible: yes
Target IC50: 670 nM against telomerase activity in TRAP lysate prepared from U937 cells

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Seimiya, H., et al. 2005. Cancer Cell7, 25.
Seimiya, H., et al. 2002. Mol. Cancer Ther.1, 657.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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