539695
PME-1 Inhibitor, AMZ-30
The PME-1 Inhibitor, AMZ-30 controls the biological activity of PME-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
PME-1 Inhibitor, AMZ-30, ( E)-2-(4-Fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)-acrylonitrile, NIH Probe ML136
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About This Item
Empirical Formula (Hill Notation):
C19H13FN3O6S2
Molecular Weight:
462.45
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
2-8°C
General description
A cell-permeable sulfonyl acrylonitrile compound that acts as a potentand irreversible inhibitor of protein phosphatase methylesterase-1(PME-1; IC50 = 600 nM and 2.5 µM in human cell lysates and in HEK 293T cells, respectively) with 100-fold greater selectivity over other serine hydrolases; does not function as a general thiol-reactive probe. Shown to lower demethylated PP2A levels by ~80% at 20 µM with elevated methylated PP2A (protein phosphatase 2A) form in PME-1 overexpressing HEK 293T cells.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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