Recommended Products
biological source
chicken
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Specificity
Recognizes Glycoprotein Po. Po is the major glycoprotein in peripheral myelin
Immunogen
Synthetic peptides from human/mouse Po.
Application
Immunohistochemistry: 1:50-1:100 using 2% paraformaldehyde fixed tissues.
Immunocytochemistry: 1:50-1:100 using 2% paraformaldehyde fixed cells.
Optimal working dilutions must be determined by the end user.
Immunocytochemistry: 1:50-1:100 using 2% paraformaldehyde fixed cells.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuronal & Glial Markers
Neuronal & Glial Markers
This Anti-Po Antibody is validated for use in IC, IH for the detection of Po.
Physical form
Affinity purified chicken IgY. Two different antibodies were combined to make this product. Liquid in PBS, pH 7.2 with 0.02% sodium azide.
Storage and Stability
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. It is recommended that the antibody be stored in the dark.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Bradley A Heller et al.
The Journal of cell biology, 204(7), 1219-1236 (2014-04-02)
The PI 3-kinase (PI 3-K) signaling pathway is essential for Schwann cell myelination. Here we have characterized PI 3-K effectors activated during myelination by probing myelinating cultures and developing nerves with an antibody that recognizes phosphorylated substrates for this pathway.
Maria Alejandra Gonzalez-Gonzalez et al.
Frontiers in neuroscience, 16, 726467-726467 (2022-06-03)
Hypertension is a main cause of death in the United States with more than 103 million adults affected. While pharmacological treatments are effective, blood pressure (BP) remains uncontrolled in 50-60% of resistant hypertensive subjects. Using a custom-wired miniature electrode, we
The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons.
Einheber, S; Meng, X; Rubin, M; Lam, I; Mohandas, N; An, X; Shrager, P; Kissil, J; Maurel et al.
Glia null
Andreas Flütsch et al.
Neuroreport, 27(18), 1305-1311 (2016-11-09)
Schwann cells (SCs) detect injury to peripheral nerves and transform phenotypically to respond to injury and facilitate repair. Cell-signaling pathways and changes in gene expression that drive SC phenotypic transformation in injury have been described; however, the SC receptors that
Brendan Zotter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(2), 183-201 (2021-11-14)
Peripheral nerves are organized into discrete compartments. Axons, Schwann cells (SCs), and endoneurial fibroblasts (EFs) reside within the endoneurium and are surrounded by the perineurium, a cellular sheath comprised of layers of perineurial glia (PNG). SC secretion of Desert Hedgehog
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