35404
5-Hydroxymebendazole
VETRANAL®, analytical standard
Synonym(s):
Methyl 5-[(RS)-α-hydroxybenzyl]-1H-benzimidazole-2-carbamate
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About This Item
Empirical Formula (Hill Notation):
C16H15N3O3
CAS Number:
Molecular Weight:
297.31
Beilstein/REAXYS Number:
4537623
UNSPSC Code:
41116107
NACRES:
NA.24
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grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
COC(=O)Nc1nc2ccc(cc2[nH]1)C(O)c3ccccc3
InChI
1S/C16H15N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9,14,20H,1H3,(H2,17,18,19,21)
InChI key
IIQKUGXEGMZCLE-UHFFFAOYSA-N
Related Categories
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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S Gupta et al.
Indian journal of experimental biology, 29(7), 645-648 (1991-07-01)
Methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis in rats and cysticercoids of Hymenolepis nana in grain beetles. The test compound offered better action than mebendazole except against
Anthelmintic activity of methyl 5(6)-(alpha-hydroxyphenyl methyl) benzimidazole-2-carbamate, a metabolite of mebendazole.
S Gupta et al.
Indian journal of experimental biology, 25(12), 871-873 (1987-12-01)
E G Iosifidou et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(3), 317-320 (1997-03-01)
Mebendazole (MBZ) is extensively used in eel culture for treatment of Pseudodactylogyrus spp. infections. This use may lead to residues of MBZ in eel tissues. Consequently, the residue profile of MBZ in eel after treatment with the drug is of
H De Ruyck et al.
The Analyst, 126(12), 2144-2148 (2002-01-30)
A quantitative liquid chromatography-electrospray tandem mass spectrometry method for the determination of mebendazole and its hydrolysed and reduced metabolites in sheep liver has been developed and validated. The benzimidazole substances were extracted with ethyl acetate after the sample mixture had
B Oosterhuis et al.
Therapeutic drug monitoring, 6(2), 215-220 (1984-01-01)
A sensitive method is described for the simultaneous determination of mebendazole and hydroxymebendazole using flubendazole as an internal standard. The analytes were isolated with a single chloroform extraction from 1.0 ml of alkalinized plasma or cyst liquid samples. Separation and
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