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D0710000

Dexamethasone acetate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Dexamethasone 21-acetate, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate

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About This Item

Empirical Formula (Hill Notation):
C24H31FO6
CAS Number:
1177-87-3
Molecular Weight:
434.50
Beilstein/REAXYS Number:
2342608
MDL number:
MFCD00027407
UNSPSC Code:
41116107
PubChem Substance ID:
329798629

biological source

synthetic

grade

pharmaceutical primary standard

agency

EP

API family

dexamethasone

packaging

pkg of 150 mg

manufacturer/tradename

EDQM

storage condition

protect from light

color

white

solubility

water: <0.1 g/L

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

ambient

storage temp.

2-8°C

SMILES string

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O

InChI

1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1

InChI key

AKUJBENLRBOFTD-RPRRAYFGSA-N

Gene Information

human ... NR3C1(2908)

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General description

Dexamethasone acetate (Decadron-LA) belongs to the class of long-acting glucocorticoids, commonly used as a pharmaceutical ingredient in creams, ointments, microemulsions, lotions, aerosols, etc.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone acetate is used as an EP reference standard to quantify the analyte in pharmaceutical formulations using chromatography ttechniques.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

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Dexamethasone acetate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 10(3), 4963-4965 (2021)
Xuefan Xu et al.
Drug delivery, 18(7), 485-492 (2011-06-23)
This work studied the intravenous injection formulation of nanostructured lipid carriers (NLCs) loaded with dexamethasone acetate (DA), a poorly water-soluble drug. The goal of this study was to design nanoparticles which could improve therapeutic efficacy of DA on inflammations. Based
Kam-Lun Ellis Hon et al.
The Journal of dermatological treatment, 19(4), 241-245 (2008-07-17)
Many parents purchase topical applications without knowing what they contain, and apply them liberally to their children with dermatological disorders. In one such case, an infant developed fever, diarrhea and a small ulcer near the right labia majora which was
T Lifshitz et al.
Ophthalmic surgery and lasers, 32(2), 159-161 (2001-04-13)
Retrocorneal membranes after penetrating keratoplasty (PKP) is a well known complications, resulting from unintentional retention of the host Descemet's membrane (DM), or donor DM detachment. We describe for the first time the formation of a retrocorneal inflammatory membrane that mimics
Sandra A L Moura et al.
Journal of pharmaceutical sciences, 100(7), 2886-2895 (2011-02-02)
Implants are defined as controlled sustained release delivery systems of therapeutic agents incorporated or dispersed into a polymeric carrier. These systems can be implanted in specific organs and delivered by the therapeutic agents at the target site to treat various
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