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N6142

Supelco

Nabumetone

analytical standard

Synonym(s):

4-(6-Methoxy-2-naphthyl)-2-butanone

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About This Item

Empirical Formula (Hill Notation):
C15H16O2
CAS Number:
42924-53-8
Molecular Weight:
228.29
MDL number:
MFCD00079518
UNSPSC Code:
41116107
PubChem Substance ID:
329818660
NACRES:
NA.24

grade

analytical standard

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

COc1ccc2cc(CCC(C)=O)ccc2c1

InChI

1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

InChI key

BLXXJMDCKKHMKV-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Nonselective non-steroidal anti-inflammatory drug (NSAID)

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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R Andrew Moore et al.
The Cochrane database of systematic reviews, (4)(4), CD007548-CD007548 (2009-10-13)
Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) used mainly in treating pain associated with arthritis. The usual oral dose for osteoarthritis is 1000 mg daily, and higher doses are not advised in older patients. There are no known systematic reviews
Applicability of LC/MS/MS assay for 6-methoxy-2-napthylacetic acid to support the bioequivalence study of nabumetone-comments on the research work of Patel et al. (2008).
Nuggehally R Srinivas
Biomedical chromatography : BMC, 23(6), 674-675 (2009-03-12)
Neha Sethi et al.
Journal of chromatographic science, 50(2), 85-90 (2012-02-03)
High efficiency and less run time are the basic requirements of high-speed chromatographic separations. To fulfill these requirements, a new separation technique, ultra-performance liquid chromatography (UPLC), has shown promising developments. A rapid, specific, sensitive, and precise reverse-phase UPLC method is
David Foley et al.
Organic & biomolecular chemistry, 7(6), 1064-1067 (2009-03-06)
Thiodipeptide prodrugs of the ketone nabumetone are shown to have affinity for, and be transported by, PepT1 in vitro.
Fixed drug eruption due to nabumetone in a patient with previous fixed drug eruptions due to naproxen.
R Pérez-Calderón et al.
Journal of investigational allergology & clinical immunology, 21(2), 153-154 (2011-04-06)
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