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PHR1015

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Diphenhydramine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

DP, DPH, 2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H21NO · HCl
CAS Number:
147-24-0
Molecular Weight:
291.82
EC Number:
205-687-2
MDL number:
MFCD00012479
UNSPSC Code:
41116107
PubChem Substance ID:
329823046
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 896
traceable to Ph. Eur. D2000000
traceable to USP 1218005

API family

diphenhydramine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Diphenhydramine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7790 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

related product

Product No.
Description
Pricing

1218005

Diphenhydramine hydrochloride, United States Pharmacopeia (USP) Reference Standard

D2600000

Diphenhydramine hydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0000135

Diphenhydramine impurity A, European Pharmacopoeia (EP) Reference Standard

1218016

Diphenhydramine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1217909

Diphenhydramine citrate, United States Pharmacopeia (USP) Reference Standard

1424209

Methylbenzhydrol, United States Pharmacopeia (USP) Reference Standard

38682

Diphenhydramine N-oxide hydrochloride, pharmaceutical impurity standard

1051602

Benzhydrol, United States Pharmacopeia (USP) Reference Standard

1218050

Diphenhydramine N-oxide, United States Pharmacopeia (USP) Reference Standard

1218027

Diphenhydramine Related Compound B, United States Pharmacopeia (USP) Reference Standard

PHR1899

Diphenhydramine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1897

Diphenhydramine Impurity B, Pharmaceutical Secondary Standard; Certified Reference Material

BP896

Diphenhydramine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR1898

Diphenhydramine N-Oxide Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1993

Diphenhydramine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2071

Benzhydrol, Pharmaceutical Secondary Standard; Certified Reference Material

BP1119

Diphenylmethanol, British Pharmacopoeia (BP) Reference Standard

PHR2268

Diphenhydramine Citrate, pharmaceutical secondary standard, certified reference material

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC6492
LRAB7790
LRAA7135
P500015

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Quantitative analysis of liquid formulations using FT-Raman spectroscopy and HPLC: The case of diphenhydramine hydrochloride in [TM="Benadryl"]
Orkoula MG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(4), 1406-1411 (2006)
Development and validation of a capillary electrophoresis method for the determination of codeine, diphenhydramine, ephedrine and noscapine in pharmaceuticals
Gomez MR, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(1), 85-90 (2005)
Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography: Stress test for stability evaluation
Barbas C, et al.
Journal of Chromatography A, 870(1), 97-103 (2000)
Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
Martinez-Algaba C, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(2), 312-321 (2006)
Andreas Papassotiropoulos et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(46), E4369-E4374 (2013-10-23)
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