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PHR1035

Supelco

Folic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
59-30-3
Molecular Weight:
441.40
Beilstein/REAXYS Number:
100781
EC Number:
200-419-0
MDL number:
MFCD00079305
UNSPSC Code:
41116107
eCl@ss:
34058014
PubChem Substance ID:
329823065
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to Ph. Eur. F0300000
traceable to USP 1286005

API family

folic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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General description

Folic acid is mostly obtained from the diet itself or from pharmaceutical drugs such as vitamin pills.† It is highly necessary to consume folic acid for the prevention of neural tube defects, mainly anencephaly and spina bifida.† It belongs to the class of water soluble B vitamins called folates. It is mainly used to fortify cereals/grains and dietary supplements.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Folic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using ultraviolet spectrophotometric technique and microemulsion electrokinetic chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7352 in the slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

F0300000

Folic acid, European Pharmacopoeia (EP) Reference Standard

1286005

Folic acid, United States Pharmacopeia (USP) Reference Standard

Y0001242

Folic acid impurity A, European Pharmacopoeia (EP) Reference Standard

Y0001243

Folic acid impurity D, European Pharmacopoeia (EP) Reference Standard

C0250000

Calcium folinate, European Pharmacopoeia (EP) Reference Standard

PHR1334

Folic Acid Impurity A, Pharmaceutical Secondary Standard; Certified Reference Material

1286027

Folic Acid Related Compound A, United States Pharmacopeia (USP) Reference Standard

1286300

10-Formylfolic acid, United States Pharmacopeia (USP) Reference Standard

1019870

4-Aminobenzoylglutamic acid, United States Pharmacopeia (USP) Reference Standard

BP937

Folic acid, British Pharmacopoeia (BP) Reference Standard

PHR2002

Folic Acid Impurity D, Pharmaceutical Secondary Standard; Certified Reference Material

Y0001979

Folic acid for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0001980

Folic acid for impurity I identification, European Pharmacopoeia (EP) Reference Standard

Y0002071

Calcium folinate for system suitability, European Pharmacopoeia (EP) Reference Standard

PHR2003

Folic Acid Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC7879
LRAD0141
LRAD2997
LRAA8965
LRAB7352

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Folic acid

Quantitative determination of folic acid in multivitamin/multielement tablets using liquid chromatography/tandem mass spectrometry
Nelson.CB, et al.
Journal of Chromatography A, 1135, 203-211 (2006)
Determination of folic acid in tablets by microemulsion electrokinetic chromatography
Aurora-Prado SM, et al.
Journal of Chromatography A, 1051(1-2), 291-296 (2004)
A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests
Matias R, et al.
Analytical Methods : Advancing Methods and Applications, 6(9), 3065-3071 (2014)
Susanna Kariluoto et al.
International journal of food microbiology, 176, 38-48 (2014-02-25)
The objective was to study folate production of yeast strains, bacteria isolated from oat bran, and selected lactic acid bacteria as well as one propionibacterium in oat and barley based models. Simultaneously, we aimed at sustaining the stability of viscosity
Vinod Devalia et al.
British journal of haematology, 166(4), 496-513 (2014-06-20)
The clinical picture is the most important factor in assessing the significance of test results assessing cobalamin status because there is no 'gold standard' test to define deficiency. Serum cobalamin currently remains the first-line test, with additional second-line plasma methylmalonic
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