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PHR1336

Supelco

Nimesulide

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Nimesulide, N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C13H12N2O5S
CAS Number:
51803-78-2
Molecular Weight:
308.31
EC Number:
257-431-4
MDL number:
MFCD00079470
UNSPSC Code:
41116107
PubChem Substance ID:
329823321
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to Ph. Eur. N0845000

API family

nimesulide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CS(NC1=C(OC2=CC=CC=C2)C=C([N+]([O-])=O)C=C1)(=O)=O

InChI

1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3

InChI key

HYWYRSMBCFDLJT-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nimesulide is a selective cyclooxygenase-2 (COX-2) inhibitor that can potentially be used as a therapeutic agent for the treatment of inflammatory conditions. It is also a non-steroidal anti-inflammatory drug (NSAID) that possesses analgesic and antipyretic characters.

Application

Nimesulide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Highly selective cyclooxygenase-2 inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA1070 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD1252
LRAC5141
LRAA9130
LRAA1070

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Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids
Nageswara Rao R, et al.
Biomedical Chromatography, 19(5), 362-368 (2005)
Validated HPTLC method for nimesulide and dicyclomine hydrochloride in formulation
Dhaneshwar SR, et al.
Journal of Pharmacy Research, 4(7), 2288-2290 (2011)
Improved high-performance liquid chromatographic assay for nimesulide
Jaworowicz Jr DJ, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 723(1-2), 293-299 (1999)
Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry
Altinoz S and Dursun OO
Journal of Pharmaceutical and Biomedical Analysis, 22(1), 175-182 (2000)
Development and validation of a novel RP-HPLC method for simultaneous determination of paracetamol, phenylephrine hydrochloride, caffeine, cetirizine and nimesulide in tablet formulation.
Dewani AP, et al.
Arabian Journal of Chemistry, 8(4), 591-598 (2015)
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