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PHR1476

Supelco

Diethyl Phthalate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Diethyl phthalate

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About This Item

Linear Formula:
C6H4-1,2-(CO2C2H5)2
CAS Number:
84-66-2
Molecular Weight:
222.24
Beilstein/REAXYS Number:
1912500
EC Number:
201-550-6
MDL number:
MFCD00009111
UNSPSC Code:
41116107
PubChem Substance ID:
329823404
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to Ph. Eur. D1410000
traceable to USP 1193505

vapor density

7.66 (vs air)

vapor pressure

1 mmHg ( 100 °C)

API family

diethyl phthalate

CofA

current certificate can be downloaded

autoignition temp.

854 °F

expl. lim.

0.75 %, 187 °F

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.502 (lit.)

bp

298-299 °C (lit.)

mp

−3 °C (lit.)

density

1.12 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCOC(=O)c1ccccc1C(=O)OCC

InChI

1S/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3

InChI key

FLKPEMZONWLCSK-UHFFFAOYSA-N

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General description

Diethyl Phthalate is a phthalic acid ester, commonly synthesized by the condensation of the carboxy groups of phthalic acid with methanol.. It is used as a solvent for fragrance in cosmetic formulations and personal care products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Diethyl Phthalate may be used as a pharmaceutical reference standard for the determination of the analyte in cosmetic products, pharmaceutical formulations and dietary supplements by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA3024 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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WGK 2

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAC9131
LRAC4368
LRAA9225
LRAA3024

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Kelley K, et al.
Environmental Health Perspectives, 120(3), 379-384 (2011)
Phthalic Acid and Derivatives
Ullmann's Encyclopedia of Industrial Chemistry (2007)
Gas chromatography in routine pharmaceutical analysis
Baines CB and Proctor KA
The Journal of Pharmacy and Pharmacology, 11(S1), 230T-234T (1959)
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