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PHR1594

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Methacycline hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Methacycline hydrochloride, 6-Demethyl-6-deoxy-6-methyleneoxytetracycline monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H22N2O8 · HCl
CAS Number:
3963-95-9
Molecular Weight:
478.88
Beilstein/REAXYS Number:
5470951
EC Number:
223-568-3
MDL number:
MFCD04972012
UNSPSC Code:
41116107
PubChem Substance ID:
329823498
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 911
traceable to USP 1397006

API family

methacycline

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

Cl[H].[H][C@@]12[C@@H](O)[C@]3([H])C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C

InChI

1S/C22H22N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-6,10,14-15,17,25,27-29,32H,1H2,2-3H3,(H2,23,31);1H/t10-,14-,15+,17+,22+;/m1./s1

InChI key

VZQARNDJLLWXGL-CCHMMTNSSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Methacycline hydrochloride is one of the tetracycline antibiotics effective against a broad-spectrum of Gram-positive and Gram-negative bacteria. It is formed as an intermediate during the preparation of oxytetracycline. Its antibacterial activity is higher than that of tetracycline and oxytetracycline. It finds applications in human and veterinary medications as well as feed additives.

Application

Methacycline hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and electroanalytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2077 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

related product

Product No.
Description
Pricing

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD3244
LRAC2077
LRAA4710

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Rapid liquid chromatographic method for simultaneous determination of tetracyclines antibiotics and 6-Epi-doxycycline in pharmaceutical products using porous graphitic carbon column
Monser L and Darghouth F
Journal of Pharmaceutical and Biomedical Analysis, 23(2-3), 353-362 (2000)
Methacycline hydrochloride
USP42-NF37
United States Pharmacopeia/National Formulary (2013)
Ion selective PVC membrane electrode for the determination of methacycline hydrochloride in pharmaceutical formulation
Aboul-Enein H, et al.
Sensors, 2(10), 424-431 (2002)
A G Kazemifard et al.
Journal of pharmaceutical and biomedical analysis, 16(4), 689-696 (1998-03-21)
A sensitive high-performance liquid chromatographic technique with amperometric detection has been developed for the determination of seven commercially used tetracyclines in bulk powders and pharmaceutical preparations. The technique is based on the oxidation of these compounds and their contaminants at

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