PHR1855
Telmisartan
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Telmisartan, 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid, BIBR 277
About This Item
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
agency
traceable to Ph. Eur. Y0000648
traceable to USP 1643419
API family
telmisartan
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C
InChI
1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChI key
RMMXLENWKUUMAY-UHFFFAOYSA-N
Gene Information
human ... AGTR1(185)
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General description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Telmisartan belongs to the class of angiotensin II receptor antagonists (ARAs) used in the treatment of hypertension.
Application
- Reversed-phase high-performance liquid chromatography (RP-HPLC) method-based multi-analysis of rosuvastatin, telmisartan, ezetimibe, and atorvastatin in pharmaceutical dosage formulations
- RP-HPLC analysis of telmisartan in the presence of its three impurities in its tablet formulation following an analytical quality-by-design (AQbD) approach
- Multi-determination of hydrochlorothiazide, amlodipine, and telmisartan by HPLC combined with spectrometric techniques without derivatization
- Simultaneous estimation of telmisartan and hydrochlorothiazide by micellar high-pressure liquid chromatography and spectrophotometry-based methods in their combined tablet formulations
- RP-HPLC method-based determination of four cardiovascular drugs—atorvastatin, simvastatin, telmisartan, and irbesartan in bulk drugs and tablet dosage forms, following ICH guidelines
Biochem/physiol Actions
Analysis Note
Footnote
related product
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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