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Y0000666

Terazosin for system suitability

Name: Terazosin for system suitability
Brand: SIAL

CRS, European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Terazosin hydrochloride dihydrate, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride dihydrate

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₅N₅O₄ · HCl · 2H₂O

CAS Number:

70024-40-7

Molecular Weight:

459.92

MDL number:

MFCD00941408

UNSPSC Code:

41116107

PubChem Substance ID:

329831082

NACRES:

NA.24

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Slide 1 of 8

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Y0000624

Terazosin impurity N

Y0002286

Terazosin for system suitability A

Y0002095

Prazosin impurity A

Sigma-Aldrich

518654

4-Amino-2-chloro-6,7-dimethoxyquinazoline

USP

1076385

Brinzolamide Related Compound B

Y0000665

Terazosin impurity E

Y0001593

Dexamethasone for peak identification

Y0002215

Primidone for system suitability

grade

pharmaceutical primary standard

API family

terazosin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O.O.Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4

InChI

1S/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2

InChI key

NZMOFYDMGFQZLS-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

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General description

Terazosin hydrochloride is a quinazoline derivative. It is a alpha-1-selective adrenoceptor blocking agent. It has been used to treat hypertension, as it helps the blood vessels to relax, expand and improves blood flow.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

It may be used as drug standard stock solution for determination of terazosin hydrochloride dihydrate using potentiometric and fluorimetric techniques.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Y0000622

Terazosin impurity A, European Pharmacopoeia (EP) Reference Standard

1643474

1643485

PHR3137

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Norepinephrine receptors have been studied in emotion, memory, and attention. However, the role of alpha1-adrenergic receptors in fear conditioning, a major model of emotional learning, is poorly understood. We examined the effect of terazosin, an alpha1-adrenergic receptor antagonist, on cued

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The purpose of this study was to elucidate the pharmacokinetics of terazosin enantiomers in healthy Chinese male subjects. After a single oral dose of 2-mg terazosin, the plasma concentrations of terazosin enantiomers were measured over the course of 48 h

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