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Y0001421

Bifonazole for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Bifonazole, 1-(p,α-Diphenylbenzyl)imidazole

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About This Item

Empirical Formula (Hill Notation):
C22H18N2
CAS Number:
60628-96-8
Molecular Weight:
310.39
MDL number:
MFCD00865567
UNSPSC Code:
41116107
PubChem Substance ID:
329831417
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

bifonazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

c1ccc(cc1)C(c2ccc(cc2)-c3ccccc3)n4ccnc4

InChI

1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H

InChI key

OCAPBUJLXMYKEJ-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Bifonazole for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Bifonazole is an imidazole-based anti-fungal agent with broad spectrum activity against many fungi, molds, yeast and some Gram-positive bacteria. Bifonazole inhibits ergosterol biosynthetic protein 28 and Cytochrome P450 2B4.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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T E Lackner et al.
Drugs, 38(2), 204-225 (1989-08-01)
Bifonazole is a substituted imidazole antifungal agent structurally related to other drugs in this group. It possesses a broad spectrum of activity in vitro against dermatophytes, moulds, yeasts, dimorphic fungi and some Gram-positive bacteria. Both non-comparative and comparative clinical trials
Ruihua Wang et al.
Obstetrics and gynecology, 124(2 Pt 2 Suppl 1), 423-425 (2014-07-09)
Majocchi granuloma is a cutaneous dermatophyte infection of the dermal and subcutaneous tissues characterized by chronic erythematous and indurated plaques, which are almost always the result of immunodeficiency and trauma. Disseminated dermatophyte Majocchi granuloma was diagnosed in a 19-year-old woman
Pénélope A Andreux et al.
Scientific reports, 4, 5285-5285 (2014-06-14)
Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has proven challenging. It requires the measurement of
Niraj S Trasi et al.
The journal of physical chemistry. B, 118(33), 9974-9982 (2014-07-31)
Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand the factors that influence

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