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B175

Sigma-Aldrich

BW 723C86

≥98% (HPLC)

Synonym(s):

α-methyl-5-(2-thienylmethoxy)-1H-Indole-3-ethanamine monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H18N2OS · HCl
CAS Number:
160521-72-2
Molecular Weight:
322.85
MDL number:
MFCD01321066
UNSPSC Code:
12352200
PubChem Substance ID:
24278284
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 1 mg/mL, clear

SMILES string

Cl.CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12

InChI

1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H

InChI key

PYJBJMIBANAOFJ-UHFFFAOYSA-N

Gene Information

human ... HTR2B(3357)

Biochem/physiol Actions

5-HT2B serotonin receptor agonist.

Caution

Hygroscopic; photosensitive

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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G A Kennett et al.
Neuropharmacology, 36(2), 233-239 (1997-02-01)
The 5-HT2B receptor agonist, BW 723C86 (10 and 20 mg/kg s.c.), increased the time spent in feeding behaviour of freely-fed rats in observation cages over 15 min. BW 723C86 (20 and 50 mg/kg s.c. 30 min pre-test) also modestly increased
G A Kennett et al.
British journal of pharmacology, 117(7), 1443-1448 (1996-04-01)
1. BW 723C86 (3 and 10 mg kg-1, s.c. 30 min pretest), a 5-HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis. 2. The effect of BW 723C86 in
Marcus Niebert et al.
PloS one, 6(7), e21395-e21395 (2011-07-27)
Neurons of the respiratory network in the lower brainstem express a variety of serotonin receptors (5-HTRs) that act primarily through adenylyl cyclase. However, there is one receptor family including 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors that are directed towards protein kinase
Raphael R Perim et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 314(5), R709-R715 (2018-02-01)
Intermittent spinal serotonin receptor activation elicits phrenic motor facilitation (pMF), a form of spinal respiratory motor plasticity. Episodic activation of either serotonin type 2 (5-HT2) or type 7 (5-HT7) receptors elicits pMF, although they do so via distinct cellular mechanisms
Yasmine Chabbi-Achengli et al.
The American journal of pathology, 186(4), 927-937 (2016-03-13)
Rheumatoid arthritis is a chronic disease that results in a disabling and painful condition as it progresses to destruction of the articular cartilage and ankylosis of the joints. Although the cause of the disease is still unknown, evidence argues that
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