Skip to Content
MilliporeSigma
All Photos(3)

Documents

C4680

Sigma-Aldrich

α-Cyclodextrin

powder, BioReagent, suitable for cell culture, ≥98%

Synonym(s):

α-Schardinger dextrin, Cyclohexaamylose, Cyclomaltohexaose

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C36H60O30
CAS Number:
10016-20-3
Molecular Weight:
972.84
Beilstein/REAXYS Number:
79627
EC Number:
233-007-4
MDL number:
MFCD00078207
UNSPSC Code:
12352201
PubChem Substance ID:
24892712
NACRES:
NA.77

sterility

non-sterile

Quality Level

200

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

>278 °C (dec.) (lit.)

solubility

H2O: 10 mg/mL

shipped in

ambient

storage temp.

room temp

SMILES string

OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@H]4CO)O[C@H]5[C@H](O)[C@@H](O)[C@H](O[C@@H]5CO)O[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]6CO)O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]1[C@H](O)[C@H]2O

InChI

1S/C36H60O30/c37-1-7-25-13(43)19(49)31(55-7)62-26-8(2-38)57-33(21(51)15(26)45)64-28-10(4-40)59-35(23(53)17(28)47)66-30-12(6-42)60-36(24(54)18(30)48)65-29-11(5-41)58-34(22(52)16(29)46)63-27-9(3-39)56-32(61-25)20(50)14(27)44/h7-54H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-/m1/s1

InChI key

HFHDHCJBZVLPGP-RWMJIURBSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

α-Cyclodextrin (α-CD) is a cyclic oligosaccharide that consists of six glucopyranose units linked by α-(1,4) bonds. α-CD acts as a soluble dietary fiber and hence it is preferred to be widely used in food industry.

Application

Useful for the solubilization of nonpolar macromolecules such as fatty acids, lipids, and cholesterol for use in cell culture applications. α-Cyclodextrin has been used to solubilize odanacatib, a cathepsin K inhibitor.

Biochem/physiol Actions

α-Cyclodextrin is found to form a firm complex with dietary fats. This way it decreases the bioavailability and absorption of fats. It is known to regulate triglyceride and leptin levels in serum. In rat models, α-Cyclodextrin is shown to induce insulin sensitivity and fecal fat excretion. Thus, α-cyclodextrin is considered to be effective for treating obesity and metabolic syndromes.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 8

1 of 8

α-Cyclodextrine for biochemistry

Millipore

1.02126

α-Cyclodextrine

β-Cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany

Sigma-Aldrich

W402826

β-Cyclodextrin

β-Cyclodextrin produced by Wacker Chemie AG, Burghausen, Germany, ≥95.0% (HPLC)

Sigma-Aldrich

779105

β-Cyclodextrin

(2-Hydroxypropyl)-β-cyclodextrin powder, BioReagent, suitable for cell culture

Sigma-Aldrich

C0926

(2-Hydroxypropyl)-β-cyclodextrin

Methyl-β-cyclodextrin powder, BioReagent, suitable for cell culture

Sigma-Aldrich

C4555

Methyl-β-cyclodextrin

β-Cyclodextrin polymer powder

Sigma-Aldrich

C2485

β-Cyclodextrin polymer

(2-Hydroxypropyl)-α-cyclodextrin average Mw ~1,180

Sigma-Aldrich

390690

(2-Hydroxypropyl)-α-cyclodextrin

(2-Hydroxypropyl)-γ-cyclodextrin solid

Sigma-Aldrich

H125

(2-Hydroxypropyl)-γ-cyclodextrin

Functional Carbohydrates: Development, Characterization, and Biomanufacture (2017)
Pulsed low-dose RANKL as a potential therapeutic for postmenopausal osteoporosis
Cline SA, et al.
JCI insight, 1(13) (2016)
The Beneficial Effects a-Cyclodextrin on Blood Lipids and Weight Loss in Healthy Humans
Comerford KB, et al
Obesity (Silver Spring, Md.), 19(6), 1200-1204 (2011)
Hidetoshi Arima et al.
Molecular pharmaceutics, 9(9), 2591-2604 (2012-08-10)
We previously reported that of the various polyamidoamine (PAMAM) STARBURST dendrimer (generation 3, G3) (dendrimer) conjugates with cyclodextrins (CyDs), the dendrimer (G3) conjugate with α-CyD having an average degree of substitution of 2.4 (α-CDE (G3)) has the greatest potential for
Yi Zhou et al.
Molecular pharmaceutics, 9(5), 1067-1076 (2012-04-10)
Safe and effective gene delivery is essential to the success of gene therapy. We synthesized and characterized a novel nonviral gene delivery system in which folate (FA) molecules were functioned as blockers on cationic polyrotaxanes (PR) composed of poly(ethylenimine) (PEI)(600)-grafted
View All Related Papers

Articles

Cyclodextrin Solubility Table

Solubility of common cell culture components in water and in a solution of 2-Hydroxylpropyl beta-cyclodextrin. Cyclodextrin is a non-toxic compound useful for its ability to solubilize fat soluble vitamins and hormones.

Cyclodextrins

Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds in tissue culture, cell culture, or other water-based applications.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service