CG10
Chorionic gonadotropin human
lyophilized powder, vial of ~10,000 IU
Synonym(s):
Choriogonin, HCG
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About This Item
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biological source
human urine
Quality Level
sterility
sterile-filtered
form
lyophilized powder
mol wt
37.9 kDa
contains
mannitol
packaging
vial of ~10,000 IU
drug control
Home Office Schedule 4.2
impurities
HBsAg, HCV and HIV-1/HIV-2, tested negative
solubility
water: 10 mL/vial, clear to slightly hazy, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... CGA(1081)
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General description
Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.
Application
Chorionic gonadotropin has been used:
- in in vitro analysis of cytotoxicity
- in egg and embryo preparations
- in the superovulation of CD-1 mice
- in gonadotropin preparations for the in vivo studies with the luteinizing hormone-releasing hormone (LHRH) agonist (LHRH-a) to synchronize naturally cycling rats.
Biochem/physiol Actions
Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Reconstitution
When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.1 M sodium phosphate buffer (pH approx. 7.2) and 10 mg/mL of mannitol.
Analysis Note
The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 10,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Calcium/calmodulin-dependent protein kinase II and calmodulin: regulators of the meiotic spindle in mouse eggs
Johnson J, et al.
Developmental Biology, 204(2), 464-477 (1998)
Unique recombinant human ribonuclease and inhibition of Kaposi's sarcoma cell growth
Newton D L and Rybak S M
Journal of the National Cancer Institute, 90(23), 1787-1791 (1998)
Reducing inositol lipid hydrolysis, Ins (1, 4, 5) P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres.
Han J K, et al.
The Journal of Cell Biology, 116(1), 147-156 (1992)
The superovulation of synchronous adult rats using follicle-stimulating hormone delivered by continuous infusion
Scott H G and Armstrong D T
Biology of Reproduction, 44(5), 851-856 (1991)
Umit A Kayisli et al.
Journal of immunology (Baltimore, Md. : 1950), 171(5), 2305-2313 (2003-08-21)
The first known hormonal signal of the conceptus during implantation is human chorionic gonadotropin (hCG). Interestingly, increased apoptosis in human endometrium coincides with the implantation window. Factors from the fetal or placental origin as well as maternal hormonal factors are
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