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CG5

Sigma-Aldrich

Chorionic gonadotropin human

lyophilized powder, vial of ~5,000 IU

Synonym(s):

Choriogonin, HCG

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About This Item

CAS Number:
9002-61-3
EC Number:
232-660-2
MDL number:
MFCD00130797
UNSPSC Code:
12352209
NACRES:
NA.32

biological source

human urine

Quality Level

200

sterility

sterile-filtered

form

lyophilized powder

mol wt

37.9 kDa

contains

mannitol

packaging

vial of ~5,000 IU

drug control

Home Office Schedule 4.2

impurities

HBsAg, HCV and HIV-1/HIV-2, tested negative

solubility

water: 10 mL/vial, clear to slightly hazy, colorless

UniProt accession no.

P01215

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... CGA(1081)

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General description

Chorionic gonadotropin human (CGA or hCG) is a heterodimer and belongs to the cystine knot growth factor superfamily. It exists as six variants namely hCGn, hCGβ, hCGβn, hCGβcf and hCGα including hCG. CGA is mapped to human chromosome 6q14.3. hCG comprises of α and β chain.
Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

Application

Chorionic gonadotropin human has been used:
  • to induce oocyte maturation in cultured follicles
  • along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice
  • as medium component for fetal testes culture to aid steroidogenic responsiveness

Biochem/physiol Actions

Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.

Reconstitution

When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.1 M sodium phosphate buffer (pH approx. 7.2) and 100 mg/mL of mannitol.

Analysis Note

The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 5,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Endocrine disruption in human fetal testis explants by individual and combined exposures to selected pharmaceuticals, pesticides, and environmental pollutants
Gaudriault P, et al.
Environmental Health Perspectives, 125(8), 087004-087004 (2017)
LH and the Male
Human Chorionic Gonadotropin (2018)
Comparison of the oocyte quality derived from two-dimensional follicle culture methods and developmental competence of in vitro grown and matured oocytes
Lee J, et al.
BioMed Research International, 2018 (2018)
Following the course of pre-implantation embryo patterning by non-linear microscopy
Kyvelidou C, et al.
Journal of Structural Biology, 176(3), 379-386 (2011)
Candidate epitopes for measurement of hCG and related molecules: the second ISOBM TD-7 workshop
Berger P, et al.
Tumor Biology, 34(6), 4033-4057 (2013)
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