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D9069

Sigma-Aldrich

N-Desmethyltamoxifen HCl

≥98% (HPLC), solid

Synonym(s):

(Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, ICI 55,548

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About This Item

Empirical Formula (Hill Notation):
C25H27NO·HCl
CAS Number:
15917-65-4
Molecular Weight:
393.95
MDL number:
MFCD03423594
UNSPSC Code:
12352203
PubChem Substance ID:
329798889
NACRES:
NA.77

sterility

non-sterile

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

technique(s)

inhibition assay: suitable

solubility

DMSO: ≥20 mg/mL

shipped in

ambient

storage temp.

room temp

SMILES string

Cl.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCNC)cc3

InChI

1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;

InChI key

GMLHJWZEYLTNJW-BJFQDICYSA-N

Application

N-Desmethyltamoxifen HCl has been used as an internal standard in high-performance liquid chromatography (HPLC) for the quantification of metabolites from NG2 cell-derived astrocytes.

Biochem/physiol Actions

N-Desmethyltamoxifen HCl is the primary metabolite of tamoxifen. N-Desmethyltamoxifen HCl is an estrogen response modifer and protein kinase C inhibitor.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes
Hackett AR, et al.
Experimental Neurobiology, 308, 72-79 (2018)

Articles

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

nuclear-receptors-steroids

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Chromatograms

application for HPLC

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