Skip to Content
MilliporeSigma
All Photos(1)

Documents

E4644

Sigma-Aldrich

Anti-Erythropoietin Receptor antibody produced in goat

affinity isolated antibody

Synonym(s):

Anti-EPO R, Anti-EPO Receptor

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
51111800
PubChem Substance ID:
24894570
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

western blot: 1 μg/mL

UniProt accession no.

P19235

storage temp.

−20°C

target post-translational modification

unmodified

SMILES string

CCCCCCCC/C=C/CCCCCCCCCC(OC(CCCCCCCC/C=C/CCCCCCCCC)=O)=O

InChI

1S/C40H74O3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-39(41)43-40(42)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17,19-20,22H,3-16,18,21,23-38H2,1-2H3/b19-17+,22-20+

InChI key

WOPZJDCVLPFUEY-ZEYSCXRRSA-N

Gene Information

human ... EPOR(2057)

Related Categories

General description

Erythropoietin Receptor (EPO R) is a protein that belongs to type I cytokine receptor superfamily and is expressed mainly in megakaryocytes, erythoid progenitors, endothelial cells and neurons. Erythropoietin binds to EPO receptor and stimulates Jak2 tyrosine kinase which in turn phosphorylate tyrosine residue of EPO receptor and results in activation of several intracellular pathways (Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors). Anti-Erythropoietin Receptor antibody can be used for analyzing the neurite outgrowth. Goat anti-Erythropoietin Receptor antibody reacts specifically with recombinant human erythropoietin receptor.

Immunogen

recombinant human erythropoietin soluble receptor, expressed in NSO cells.

Application

Anti-Erythropoietin Receptor can be used in western blotting at a working antibody concentration of 1 μg/ml for detecting human EPO receptor.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The erythropoietin receptor and the molecular basis of signal transduction.
D L Barber et al.
Seminars in hematology, 29(4), 293-304 (1992-10-01)
Stanislava Pankratova et al.
Journal of neurochemistry, 121(6), 915-923 (2012-04-04)
Apart from its hematopoietic activity, erythropoietin (EPO) is also known as a tissue-protective cytokine. In the brain, EPO and its receptor are up-regulated in response to insult and exert pro-survival effects. EPO binds to its receptor (EPOR) via high- and
Structure, function, and activation of the erythropoietin receptor.
H Youssoufian et al.
Blood, 81(9), 2223-2236 (1993-05-01)
Erythropoietin receptors: their role beyond erythropoiesis.
Jerome Rossert et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 20(6), 1025-1028 (2005-04-21)
María José Vázquez-Mellado et al.
Oncology reports, 41(2), 1333-1341 (2018-11-30)
Erythropoietin (Epo) is used for the treatment of cancer‑associated anaemia. However, certain studies have identified that the administration of Epo mediates the acquisition of resistance to cisplatin, which is widely used to treat cervical cancer. Our group previously reported that
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service