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H4001

Sigma-Aldrich

Hydrocortisone

≥98% (HPLC)

Synonym(s):

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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About This Item

Empirical Formula (Hill Notation):
C21H30O5
CAS Number:
50-23-7
Molecular Weight:
362.46
Beilstein/REAXYS Number:
1354819
EC Number:
200-020-1
MDL number:
MFCD00011654
UNSPSC Code:
51111800
PubChem Substance ID:
24278466
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

300

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

mp

211-214 °C (lit.)

solubility

water: 0.28 g/L at 25 °C

application(s)

cell analysis

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126)
rat ... Ar(24208) , Nr3c1(24413)

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Biochem/physiol Actions

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1A - STOT RE 2

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Margriet A B Veldhorst et al.
The Journal of clinical endocrinology and metabolism, 99(1), 285-290 (2014-01-05)
Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity. The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children.
Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
K J Rademaker et al.
Archives of disease in childhood. Fetal and neonatal edition, 93(1), F58-F63 (2007-09-13)
The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects
Liselotte van Bloemendaal et al.
Diabetes, 63(12), 4186-4196 (2014-07-30)
Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in
Rachel Yehuda et al.
The American journal of psychiatry, 171(8), 872-880 (2014-05-17)
Differential effects of maternal and paternal posttraumatic stress disorder (PTSD) have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor sensitivity and vulnerability to psychiatric disorder. The authors examined the relative influences of maternal and paternal PTSD
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