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PRS3627

Sigma-Aldrich

Anti-LAMP-2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Lysosomal-associated membrane protein 2

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About This Item

MDL number:
MFCD01864612
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P17047

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Lamp2(16784)

General description

Lamp2 (lysosome-associated membrane protein gene)is located in the lysosomal lumen and lysosomal membrane. However upon chronic acidosis in the tumour microenvironment, it is found to be present in the plasma membrane.

Immunogen

a 17 amino acid peptide from near the center of human LAMP-2.

Application

Anti-LAMP-2 antibody has been used in immunofluorescence and western blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

Biochem/physiol Actions

LAMP2 (lysosome-associated membrane protein gene) preserves lysosomal membranes from acid proteolysis. It serves as an acidity biomarker in spheroids and xenografts. It also has some role in maturation of autophagic vacuoles and cell-cell or cell-extracellular matrix adhesion. Reduction of LAMP2 (lysosome-associated membrane protein gene) can increase acidosis-mediated toxicity. Mutation in LAMP2 can cause cardiomyopathy in young patients.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3627.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation
Kao C, et al.
Cell Death & Disease, 5 (2014)
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
Tanaka Y, et al.
Nature (2000)
Tobias Boothe et al.
Molecular metabolism, 5(5), 366-378 (2016-04-26)
The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was to determine the
Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells
Boothe T, et al.
Molecular Metabolism, 5(5), 366-378 (2016)
Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
Damaghi M, et al.
Nature Communications, 6:8752 (2015)
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