Skip to Content
MilliporeSigma
All Photos(1)

Documents

PZ0364

Sigma-Aldrich

DIBA-1

≥97% (NMR)

Synonym(s):

2,2′-Disulfanediylbis(N-(4-sulfamoylphenyl)benzamide, 2,2′-Dithiobis[N-[4-(aminosulfonyl)phenyl]benzamide], NSC 654077, PD022551

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C26H22N4O6S4
CAS Number:
171744-39-1
Molecular Weight:
614.74
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

assay

≥97% (NMR)

form

powder

color

white to light brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

InChI

1S/C26H22N4O6S4/c27-39(33,34)19-13-9-17(10-14-19)29-25(31)21-5-1-3-7-23(21)37-38-24-8-4-2-6-22(24)26(32)30-18-11-15-20(16-12-18)40(28,35)36/h1-16H,(H,29,31)(H,30,32)(H2,27,33,34)(H2,28,35,36)

InChI key

FVGJPHFQQMQGFQ-UHFFFAOYSA-N

Biochem/physiol Actions

DIBA-1 (2,2′-dithiobisbenzamide-1) is a disulfide that interacts with zinc fingers as a zinc ejector. It has been shown to interact with many zinc finger containing proteins, including HIV-1 nucleocapsid and the estrogen receptor. DIBA-1 has been studied as a candidate for the treatment of AIDS and also breast cancer. In one study DIBA restored tamoxifen sensitivity in resistant breast cancer.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Li Hua Wang et al.
Cancer cell, 10(6), 487-499 (2006-12-13)
A serious obstacle to successful treatment of estrogen receptor (ER)-positive human breast cancer is cell resistance to tamoxifen (TAM) therapy. Here we show that the electrophile disulfide benzamide (DIBA), an ER zinc finger inhibitor, blocks ligand-dependent and -independent cell growth
Kevin Carayon et al.
Nucleic acids research, 38(11), 3692-3708 (2010-02-19)
HIV-1 integrase catalyzes the insertion of the viral genome into chromosomal DNA. We characterized the structural determinants of the 3'-processing reaction specificity--the first reaction of the integration process--at the DNA-binding level. We found that the integrase N-terminal domain, containing a
M Huang et al.
Journal of medicinal chemistry, 41(9), 1371-1381 (1998-05-23)
Agents that target the two highly conserved Zn fingers of the human immunodeficiency virus (HIV) nucleocapsid p7 (NCp7) protein are under development as antivirals. These agents covalently modify Zn-coordinating cysteine thiolates of the fingers, causing Zn ejection, loss of native

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service