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S193

Sigma-Aldrich

Anti-Synapsin I antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-EPILX, Anti-MRX50, Anti-SYN1a, Anti-SYN1b, Anti-SYNI

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About This Item

MDL number:
MFCD00282157
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

antigen ~80 kDa (Synapsin Ia)

species reactivity

rat, mouse, human, bovine

technique(s)

dot blot: 1:1000
immunohistochemistry (frozen sections): 1:2000
immunoprecipitation (IP): 1 μg
indirect immunofluorescence: 1:2000
western blot: 1:1000

UniProt accession no.

P17600

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SYN1(6853)
mouse ... Syn1(20964)
rat ... Syn1(24949)

General description

Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23.

Immunogen

synapsin I from bovine brain.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.


Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.

Biochem/physiol Actions

Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders.

Physical form

Lyophilized from ammonium bicarbonate (5 mM)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356? mutation in synapsin I.
Giannandrea M, et al.
PLoS ONE, 8(6), e67724-e67724 (2013)
Synapsin III: role in neuronal plasticity and disease.
Porton B, et al.
Seminars in Cell & Developmental Biology, 22(4), 416-424 (2011)
Increased synapsin I expression in cerebral malaria.
Thonsranoi K, et al.
International Journal of Clinical and Experimental Pathology, 8(11), 13996-13996 (2015)
P De Camilli et al.
The Journal of cell biology, 96(5), 1337-1354 (1983-05-01)
Synapsin I (formerly referred to as protein I) is the collective name for two almost identical phosphoproteins, synapsin Ia and synapsin Ib (protein Ia and protein Ib), present in the nervous system. Synapsin I has previously been shown by immunoperoxidase
Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.
Huttner W B, et al.
The Journal of Cell Biology, 96(5), 1374-1388 (1983)
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