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SAB2501668

Sigma-Aldrich

Anti-UCHL1 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

PARK5, PGP9.5, PGP95, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

canine, bovine, rat, rabbit, pig, human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P09936

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... UCHL1(7345)

General description

Ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinase which is part of the ubiquitin proteasome system (UPS). The protein is expressed in the nervous system and gonads. The gene encoding UCHL1 is localized on human chromosome 4p13.

Immunogen

Peptide with sequence EVRFSAVALCK, from the C-terminal region of the protein sequence according toNP_004172.2

Biochem/physiol Actions

Ubiquitin C-terminal hydrolase L1 (UCHL1) has a role in epithelial-mesenchymal transition. It also has roles in invasion and in the cell cycle. UCHL1 catalyzes the hydrolysis of carboxy-terminal ubiquitin esters and amides. The protein has been associated with various cancers.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Priyanka Modi
Mental and Behavioural Disorders and Diseases of the Nervous System (2016)
UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma.
YAng H
International Journal of Clinical and Experimental Pathology (2015)
Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma.
Sanchez-diaz PC
PLoS ONE (2017)

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