SAB4300701
Anti-Id2 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-GIG8, Anti-ID2A, Anti-ID2H
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~15 kDa
species reactivity
rat, mouse, human
concentration
1 mg/mL
technique(s)
western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(S-P-V-R-S)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... Id2(3398)
General description
Id2 (inhibitor of DNA binding 2) belongs to the HLH (helix–loop–helix) family. It is located on human chromosome 2p25.
The antibody detects endogenous level of total Id2 protein.
Immunogen
Peptide sequence around aa. 5-9 (S-P-V-R-S), according to the protein NP_002157.2
Biochem/physiol Actions
Id2 (inhibitor of DNA binding 2) knockdown decreases the upregulation of N-cadherin, vimentin and Snail and promotes the expression of E-cadherin. It has the ability to interact with Rb protein and block its antiproliferative activity. It can prevent the separation of cells, stimulate multiplication of cell and help in reprogramming of Hodgkin lymphoma cells, the oncogenic AP-1 transcription factor FRA2 (fos-related antigen 2) and the oncogenic tyrosine kinase CSF-1 receptor.
Features and Benefits
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Target description
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
The Role of Id2 Protein in Neuroblatoma in Children
Wieczorek A and Balwierz W
Pathology Oncology Research, 21(4), 999-1004 (2015)
Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells
Sumida T, et al.
Genes Cells, 21(8), 915-920 (2016)
Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma
Mathas S, et al.
Proceedings of the National Academy of Sciences of the USA, 106(14), 5831-5836 (2009)
Ivan Ferrer-Vicens et al.
Cellular and molecular life sciences : CMLS, 71(18), 3583-3597 (2014-02-28)
The inhibitor of differentiation Id2, a protein lacking the basic DNA-binding domain, is involved in the modulation of a number of biological processes. The molecular mechanisms explaining Id2 pleiotropic functions are poorly understood. Id2 and E2F4 are known to bind
Sameer S Bajikar et al.
Developmental cell, 43(4), 418-435 (2017-11-22)
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous carcinoma in which various tumor-suppressor genes are lost by mutation, deletion, or silencing. Here we report a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11) and an unusual mechanism of
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