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SAB4500345

Sigma-Aldrich

Anti-CNR1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CANN6, CB-R, CB1, CNR1, Cannabinoid receptor 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 52 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P21554

UniProt accession no.

P21554

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CNR1(1268)

Related Categories

General description

Anti-CNR1 Antibody detects endogenous levels of total CNR1 protein.
CNR1 (cannabinoid receptor 1) is a member of the class A G protein-coupled receptor (GPCR) family. It is also known as the type-1 cannabinoid receptor (CB1). It is expressed at high level in the brain and the central nervous system. It is located on human chromosome 6q15.

Immunogen

The antiserum was produced against synthesized peptide derived from human CNR1.

Immunogen Range: 151-200

Biochem/physiol Actions

CNR1 (cannabinoid receptor 1) participates in most of the activities of the brain and body. It is sensitive to hebephrenic schizophrenia. Experimental studies hypothesize that aberrations in CNR1 gene increases the risk of susceptibility to substance abuse.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia.
Ujike H, et al.
Molecular Psychiatry, 7(5), 515-515 (2002)
Cannabinoid receptor gene (CNR1): association with iv drug use.
Comings DE, et al.
Molecular Psychiatry, 2(2), 161-161 (1997)
The incentive salience of alcohol: translating the effects of genetic variant in CNR1.
Hutchison KE, et al.
Archives of General Psychiatry, 65(7), 841-850 (2008)
The CB1 receptor as the cornerstone of exostasis.
Piazza PV, et al.
Neuron, 93(6), 1252-1274 (2017)
Crystal structure of the human cannabinoid receptor CB 1.
Hua T, et al.
Cell, 167(3), 750-762 (2016)
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