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SAB4501063

Sigma-Aldrich

Anti-GABBR1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

γ-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABBR1, Gb1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 108 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q9UBS5

UniProt accession no.

Q9UBS5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GABBR1(2550)

Related Categories

General description

Anti-GABBR1 Antibody detects endogenous levels of total GABBR1 protein.
The γ-aminobutyric acid type B (GABAB) receptor is coded by the GABBR1 gene. It has 22 exons and spans at least 18 kb. GABAB geneis present between an olfactory receptor gene cluster downstream and the HLA (human leukocyte antigen) class I region upstream. It is mapped to human chromosome 6p22.

Immunogen

The antiserum was produced against synthesized peptide derived from human GABBR1.

Immunogen Range: 891-940

Biochem/physiol Actions

The γ-aminobutyric acid type B (GABAB) is essential for the initiation by agonists like GABA (gamma-aminobutyric acid ). GABAB receptors participates in response habituation. In the visual cortex, GABAB is also involved in the initiation of orientation tuning in conjunction with GABAA receptors.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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GABBR1 has a HERV-W LTR in its regulatory region?a possible implication for schizophrenia.
Hegyi H.
Biology Direct, 8(1), 5-5 (2013)
Association between Single Nucleotide Polymorphisms in Gamma-Aminobutyric Acid B Receptor, Insulin Receptor Substrate-1, and Hypocretin Neuropeptide Precursor Genes and Susceptibility to Obstructive Sleep Apnea Hypopnea Syndrome in a Chinese Han Population.
Li Z, et al.
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 25(6), 517-524 (2016)
Different roles for GABAA and GABAB receptors in visual processing in the rat superior colliculus.
Binns KE and Salt TE
The Journal of Physiology, 504(3), 629-639 (1997)
GABBR 1 and SLC 6A1, Two Genes Involved in Modulation of GABA Synaptic Transmission, Influence Risk for Alcoholism: Results from Three Ethnically Diverse Populations.
Enoch MA, et al.
Alcoholism, Clinical and Experimental Research, 40(1), 93-101 (2016)

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