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SAB4501255

Sigma-Aldrich

Anti-LAMA1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

LAMA, LAMA1, Laminin A chain, Laminin subunit α-1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 337 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500

NCBI accession no.

P25391

UniProt accession no.

P25391

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LAMA1(284217)

General description

Anti-LAMA1 Antibody detects endogenous levels of total LAMA1 protein.
Laminins are extracellular matrix proteins. The LAMA1 (laminin subunit α 1) gene is mapped to chromosome 18p11.

Immunogen

The antiserum was produced against synthesized peptide derived from human LAMA1.

Immunogen Range: 2501-2550

Application

Anti-LAMA1, C-Terminal antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

LAMA1 (laminin subunit α 1) participates in several diseases like cancer, infections, inflammatory diseases and autoimmune disorders. Mutations in LAMA1 result in cerebellar dysplasia and cysts with and without retinal dystrophy. LAMA1 is also essential in the assembly of basement membrane and early growth of embryo.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mutations in LAMA1 cause cerebellar dysplasia and cysts with and without retinal dystrophy
Aldinger KA, et al.
American Journal of Human Genetics, 95, 227-234 (2014)
?3 Chains of type V collagen regulate breast tumour growth via glypican-1
Huang G, et al.
Nature Communications, 8 (2017)
Vertebrate evolution by interspecific hybridisation--are we polyploid?
Spring J
Febs Letters, 400, 2-8 (1997)
Autoimmunity against laminins
Florea F, et al.
Clinical Immunology (Orlando, Fla.), 170, 39-52 (2016)
Guorui Huang et al.
Nature communications, 8, 14351-14351 (2017-01-20)
Pericellular α3(V) collagen can affect the functioning of cells, such as adipocytes and pancreatic β cells. Here we show that α3(V) chains are an abundant product of normal mammary gland basal cells, and that α3(V) ablation in a mouse mammary

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