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SAB4501323

Sigma-Aldrich

Anti-GRM5 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

GPRC1E, GRM5, MGLUR5, Metabotropic glutamate receptor 5, mGluR5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 132 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

P41594

UniProt accession no.

P41594

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRM5(2915)

General description

Glutamate metabotropic receptor 5 (GRM5)/metabotropic glutamate receptor subtype 5 (mGluR5) is a seven-transmembrane G-protein-coupled protein. It contains two binding sites and a structural connection to the N-methyl-D-aspartate receptor (NMDA) through a scaffold protein chain. GRM5 gene is located on human chromosome 11q14.2. Anti-GRM5 antibody detects endogenous levels of total GRM5 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human GRM5.

Immunogen Range: 21-70

Biochem/physiol Actions

Glutamate metabotropic receptor 5 (GRM5) protein participates in glutamate signaling, supporting the action of natural stimuli, the excitability of N-methyl-D-aspartate receptor (NMDA) receptor, and abnormal synaptic plasticity in addiction. It is important for the pathophysiology and to treat eating disorders. It controls the developmental variation dependent on glutamate. It also plays a key role in adaptive synaptic plasticity, long-term potentiation, and learning. The pharmacological inhibitors of mGlu5 may have a therapeutic possibility in Bulimia nervosa (BN). Absence of mGluR5 plays a pathogenic role in autism spectrum disorder (ASD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Yoan Mihov et al.
Scientific reports, 10(1), 6374-6374 (2020-04-15)
Bulimia nervosa (BN) shares central features with substance-related and addictive disorders. The metabotropic glutamate receptor subtype 5 (mGlu5) plays an important role in addiction. Based on similarities between binge eating and substance-related and addictive disorders, we investigated mGlu5 in vivo
James Robert Brašić et al.
International journal of molecular sciences, 22(6) (2021-04-04)
Multiple lines of evidence suggest that dysfunction of the metabotropic glutamate receptor subtype 5 (mGluR5) plays a role in the pathogenesis of autism spectrum disorder (ASD). Yet animal and human investigations of mGluR5 expression provide conflicting findings about the nature

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