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SAB4503194

Sigma-Aldrich

Anti-Calmodulin antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CALM, CALM1, CALM2, CALM3, CAM

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About This Item

MDL number:
MFCD00162206
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 16 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P62158

UniProt accession no.

P0DP23

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CALM1(801)

Related Categories

General description

Anti-Calmodulin Antibody detects endogenous levels of total Calmodulin protein.
Calmodulin (CaM), a highly conserved Ca2+-binding protein, is mapped to human chromosome 14q32. Calmodulin is a small protein abundantly present in the brain and coded by three genes (CALM1-3).

Immunogen

The antiserum was produced against synthesized peptide derived from human Calmodulin.

Immunogen Range: 46-95

Application

Anti-Calmodulin antibody has been used in western blotting.

Biochem/physiol Actions

Calmodulin (CaM) possesses Ca2+-dependent modulatory roles. It participates in cell proliferation and muscle activity. Calmodulin plays a major role in catecholaminergic polymorphic ventricular tachycardia (CPVT) and in long QT syndrome (LQTS). This protein modulates the transcriptional processes required for proper heart function.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity and Cardiac Function in Zebrafish.
Berchtold MW, et al.
The Journal of Biological Chemistry, 291(52), 26636?26646-26636?26646 (2016)
Paeoniflorin, the Main Active Ingredient of Shuyu Capsule, Inhibits Cav1. 2 and Regulates Calmodulin/Calmodulin-Dependent Protein Kinase II Signalling.
Song C, et al.
BioMed Research International, 2017 (2017)
Orthologs of seven genes (AKT1, CDC42BPB, DIO3, EIF5, JAG2, KLC, NDUFB1) from human chromosome 14q32 map to distal chicken chromosome 5.
Boyd Y, et al.
Mammalian Genome, 13(2), 120-122 (2002)
Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.
Rocchetti M, et al.
Cardiovascular Research, 113(5), 531-541 (2017)
Presynaptic Calmodulin targets: lessons from structural proteomics.
Lipstein N, et al.
Expert Review of Proteomics, 14(3), 223-242 (2017)
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