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SAB4503250

Sigma-Aldrich

Anti-CAMK2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

CAMK2A, CaM-kinase II α chain, CaMK-II α subunit, CaMKII-α, Calcium/calmodulin-dependent protein kinase type II α chain

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 54 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q9UQM7

UniProt accession no.

Q13557

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CAMK2A(815)

General description

Anti-CAMK2 Antibody detects endogenous levels of total CAMK2 protein.
Calcium/calmodulin dependent protein kinase II α (CAMK2) is a calcium-activated serine/threonine kinase. The gene is located on human chromosome 5q32. CAMK2 is mainly expressed in the central nervous system. It consists of a kinase domain, a regulatory domain and an association domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human CaMK2 alpha/delta.

Immunogen Range: 256-305

Biochem/physiol Actions

Calcium/calmodulin dependent protein kinase II α (CAMK2) is essential for long-term potentiation (LTP) and spatial memory. It regulates synaptic plasticity. Dysfunction in this gene is associated with schizophrenia, epilepsy and autism spectrum disorders.
Calmodulin dependent protein kinase II complex δ (CAMK2D) modulates the functions of ion channels and Ca2+ handling proteins. It also regulates the phosphorylation and acetylation of histones. It has been shown to be overexpressed in the myocardium of diabetic patients.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Genes for fibrogenesis in the determination of susceptibility to myocardial infarction
Goncharova IA, et al.
Molecular Biology, 50(1), 81-90 (2016)
Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders
Wesseling H, et al.
The International Journal of Neuropsychopharmacology, 18(1) (2015)
A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability
Chia PH, et al.
eLife, 7, e32451-e32451 (2018)
De novo variants in CAMK 2A and CAMK 2B cause neurodevelopmental disorders
Akita T, et al.
Annals of Clinical and Translational Neurology, 5(3), 280-296 (2018)
Lorna Daniels et al.
Heart failure reviews, 20(5), 589-600 (2015-07-23)
Diabetes mellitus (DM) is an increasing epidemic that places a significant burden on health services worldwide. The incidence of heart failure (HF) is significantly higher in diabetic patients compared to non-diabetic patients. One underlying mechanism proposed for the link between
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