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SAB4503227

Sigma-Aldrich

Anti-OR51E2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

HPRAJ, OR51E2, Olfactory receptor 51E2, Olfactory receptor OR11-16, Prostate-specific G-protein coupled receptor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 35 kDa

species reactivity

rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q9H255

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... O51E2(81285)

General description

Anti-OR51E2 Antibody detects endogenous levels of total OR51E2 protein.

OR51E2 (olfactory receptor family 51 subfamily E member 2),also known as PSGR, codes for a G-protein–coupled receptor. It is a member of the odorant receptors family. OR51E2 is present in early endosomes. It is mapped to human chromosome 11p15.

Immunogen

The antiserum was produced against synthesized peptide derived from human OR51E2.

Immunogen Range: 221-270

Biochem/physiol Actions

OR51E2 (olfactory receptor family 51 subfamily E member 2) helps to mediate rapid, non-genomic, steroidal signaling in prostate cancer cells. It also promotes the growth of early prostate cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes
Gelis L, et al.
The Journal of Biological Chemistry, 291(34), 17772-17786 (2016)
Lian Gelis et al.
Experimental dermatology, 26(7), 569-576 (2017-02-14)
We identified the olfactory receptor 51E2 in human melanoma and have measured both OR51E2 mRNA and protein expression in melanoma tissue sections. qPCR analysis revealed that the receptor is upregulated in melanoma cells compared to normal melanocytes, indicating that OR51E2
The Cancer Genome Atlas Clinical Explorer: a web and mobile interface for identifying clinical-genomic driver associations
Lee H, et al.
Genome Medicine, 7(1), 112-112 (2015)
Nikolina Jovancevic et al.
Frontiers in physiology, 8, 888-888 (2017-12-19)
The odorant receptor 51E2 (OR51E2), which is well-characterized in prostate cancer cells and epidermal pigment cells, was identified for the first time as the most highly expressed OR in human fetal and adult retinal pigment epithelial (RPE) cells. Immunofluorescence staining
Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers
Weng J, et al.
International Journal of Cancer. Journal International Du Cancer, 113(5), 811-818 (2005)
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