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SML1451

Sigma-Aldrich

MI192 hydrochloride

≥98% (HPLC)

Synonym(s):

N-(2-Aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-benzamide hydrochloride, MI-192 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C24H21N3O2 · xHCl
CAS Number:
1415340-63-4
Molecular Weight:
383.44 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825890
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

C=C(CN1CC2=CC=C(C(NC3=CC=CC=C3N)=O)C=C2)C4=CC=CC=C4C1=O

InChI

1S/C24H21N3O2/c1-16-14-27(24(29)20-7-3-2-6-19(16)20)15-17-10-12-18(13-11-17)23(28)26-22-9-5-4-8-21(22)25/h2-13H,1,14-15,25H2,(H,26,28)

InChI key

GTLTXEIKQVWSRF-UHFFFAOYSA-N

Biochem/physiol Actions

MI192 is a potent and selective histone deacetylase 3 (HDAc 3) inhibitor that inhibits IL-6 production in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) but not healthy PBMCs.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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