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SML1948

Sigma-Aldrich

S1QEL1.1

≥98% (HPLC)

Synonym(s):

N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide, S1QEL

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About This Item

Empirical Formula (Hill Notation):
C23H24N4O3S
CAS Number:
897613-29-5
Molecular Weight:
436.53
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC1=C(CCNC(C(NC2=CC=CC(NC(C)=O)=C2)=O)=O)SC(C3=CC=C(C)C=C3)=N1

Application

S1QEL1.1 has been used as a reverse electron transport (RET)-induced mitochondrial (mito) reactive oxygen species (ROS) suppressor:
  • to investigate the role of mitochondrial-derived superoxide in triggering ferroptosis
  • to study the mechanism involved in the regulation of anti-fungal responses of macrophages against Aspergillus infection
  • in combination with mito-antioxidant to study their influence on mitochondria-derived H2O2 in cancer cells
  • to determine the effect of oxidative stress depletion on myoblast differentiation

Biochem/physiol Actions

S1QEL1.1 is a suppressor of mitochondrial respiratory complex I site IQ electron leak, suppressing superoxide and/or H2O2 production without altering oxidative phosphorylation. S1QEL1.1 had an IC50 values of 70 nM against superoxide-H2O2 production from site IQ. It decreased caspase activation in a in a cardiomyocyte cell model of ER stress and decreased ischemia-reperfusion injury in the Langendorff-perfused mouse heart model.
Suppressors of the site IQ electron leak (S1QEL)1.1 reduces cytokine secretion and fungicidal activity of macrophages infected with swollen A. fumigatus conidia by suppressing reverse electron transport (RET)-induced mitochondrial reactive oxygen species (ROS).

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Martin D Brand et al.
Cell metabolism, 24(4), 582-592 (2016-09-27)
Using high-throughput screening we identified small molecules that suppress superoxide and/or H
Takujiro Homma et al.
Archives of biochemistry and biophysics, 700, 108775-108775 (2021-01-26)
Ferroptosis is a type of iron-dependent, non-apoptotic cell death, which is typically induced by cysteine starvation or by the inhibition of glutathione peroxidase 4 (GPX4) activity with the accompanying elevation in lipid peroxidation product levels. Despite the central role of
Remi Hatinguais et al.
Frontiers in immunology, 12, 641495-641495 (2021-04-13)
Reactive Oxygen Species (ROS) are highly reactive molecules that can induce oxidative stress. For instance, the oxidative burst of immune cells is well known for its ability to inhibit the growth of invading pathogens. However, ROS also mediate redox signalling

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