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SML2111

Sigma-Aldrich

GSK8814

≥98% (HPLC)

Synonym(s):

8-((3R,4R,5S)-3-((4,4-Difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-ylamino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one, 8-[[(3R,4R,5S)-3-[(4,4-Difluorocyclohexyl)methoxy]-5-methoxy-4-piperidinyl]amino]-3-methyl-5-(5-methyl-3-pyridinyl)-1,7-naphthyridin-2(1H)-one

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About This Item

Empirical Formula (Hill Notation):
C28H35F2N5O3
CAS Number:
1997369-78-4
Molecular Weight:
527.61
UNSPSC Code:
51111800
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

colorless to very dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N1)C(C)=CC2=C1C(N[C@H]3[C@H](OCC4CCC(F)(F)CC4)CNC[C@@H]3OC)=NC=C2C5=CN=CC(C)=C5

Related Categories

Biochem/physiol Actions

GSK8814 is an aqueous soluble (>439 μM) inhibitor that targets ATAD2 & ATAD2B bromodomain (BD) with submicromolar affinity (pKd = 8.1 for ATAD2 by ITC) and high selectivity (pIC50 = 7.3/ATAD2 BD & 7.7/ATAD2B BD in competitive ligand binding assays by TR-FRET; pIC50 ≤4.5 when using BD1/BD2 of BRD2-4 or BRDT). When tested using intact cells, GSK8814 effectively disrupts histone H3.3 interaction with ATAD2 BD construct (IC50 = 2.7 μM), but not full-length ATAD2. GSK8814, but not its less active diastereomer GSK8815, is shown to suppress LNCaP colony formation in a soft agar assay, albeit with a high effective concentration (by 56% at 20 μM).

wgk_germany

WGK 3

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Paul Bamborough et al.
Angewandte Chemie (International ed. in English), 55(38), 11382-11386 (2016-08-18)
ATAD2 is a cancer-associated protein whose bromodomain has been described as among the least druggable of that target class. Starting from a potent lead, permeability and selectivity were improved through a dual approach: 1) using CF2 as a sulfone bio-isostere

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