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SML2975

Sigma-Aldrich

Dabcyl-KTSAVLQSGFRKME-Edans trifluoroacetate

≥95% (HPLC), powder, FRET substrate of SARS-CoV Mpro

Synonym(s):

DABCYL-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS trifluoroacetate, N2-[4-[[4-(Dimethylamino)phenyl]azo]benzoyl]-L-lysyl-L-threonyl-L-seryl-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-L-lysyl-L-methionyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-α-glutamine trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C95H141N25O24S2 · xC2HF3O2
CAS Number:
730985-86-1
Molecular Weight:
2081.42 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Dabcyl-KTSAVLQSGFRKME-Edans trifluoroacetate, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

light brown to dark red

storage temp.

−20°C

Biochem/physiol Actions

Dabcyl-KTSAVLQSGFRKME-Edans is a fluorescence resonance energy transfer (FRET) substrate for SARS-CoV main protease Mpro (also called 3CLpro) (538 nm with excitation at 355 nm). Dabcyl-KTSAVLQSGFRKME-Edans is suitable to measure protease activity of COVID-19 virus Mpro, SARS-CoV Mpro, and other viruses.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Linlin Zhang et al.
Journal of medicinal chemistry, 63(9), 4562-4578 (2020-02-12)
The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate. Because of their unique specificity and essential role in viral polyprotein

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