SRP6576
CREB Binding Protein (1081-1197) GST tag human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
CBP, CREBBP, cAMP-responsive element-binding protein 1 CREB-1
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
40.8 kDa (1081-1197 aa + NT GST Tag)
packaging
pkg of 20 and 100 μg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CREB1(1385)
General description
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The cAMP response element-binding protein (CREB) binding protein (CREBBP) bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53. This product contains the bromodomain region of CREBBP.
Physical form
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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