Skip to Content
MilliporeSigma
All Photos(1)

Documents

T8931

Sigma-Aldrich

Thyrotropic hormone from bovine pituitary

Synonym(s):

TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

CAS Number:
9002-71-5
MDL number:
MFCD00166060
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

bovine pituitary glands

Quality Level

200

form

powder

packaging

vial of 100 μg

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P01223
P16473

storage temp.

2-8°C

Gene Information

cow ... TSHB(281552)
human ... TSHR(7253)

Looking for similar products? Visit Product Comparison Guide

General description

Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.

Application

Thyrotropic hormone from bovine pituitary has been used:
  • to induce cAMP production in orbital fibroblasts.
  • as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
  • for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
  • for studying the thyrotropin involvement in photoperiodic signal transduction in mice.

Biochem/physiol Actions

Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Quality

Contains phosphate buffer salts

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Concentration of thyrotropic hormone in persons occupationally exposed to lead, cadmium and arsenic
Jurdziak M, et al.
Biological trace element research, 182(2), 196-203 (2018)
Disorders of the Hypothalamic-Pituitary-Thyroid Axis
Handbook of Neuroendocrinology, 685-706 (2012)
Endocrine System
Fundamentals of Toxicologic Pathology, 513-551 (2010)
Gen Hiyama et al.
Scientific reports, 8(1), 10012-10012 (2018-07-04)
Biased mating due to female preferences towards certain traits in males is a major mechanism driving sexual selection, and may constitute an important evolutionary force in organisms with sexual reproduction. In birds, although the role of male ornamentation, plumage coloration
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma
Lal G, et al.
Cancer, 107(12), 2752-2759 (2006)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service