Skip to Content
MilliporeSigma
All Photos(1)

Documents

1314009

USP

Hydrochlorothiazide

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C7H8ClN3O4S2
CAS Number:
58-93-5
Molecular Weight:
297.74
MDL number:
MFCD00051765
UNSPSC Code:
41116107
PubChem Substance ID:
329750021
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

hydrochlorothiazide

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl

InChI

1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

InChI key

JZUFKLXOESDKRF-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrochlorothiazide USP reference standard for use in specified quality tests and assays.

Also used to prepare standard, standard stock, system suitability, Hydrochlorothiazide standard solutions for assay, performance, and impurity analysis according to given below monographs of the United States Pharmacopeia (USP):
  • Hydrochlorothiazide Capsules
  • Amiloride Hydrochloride and Hydrochlorothiazide Tablets
  • Captopril and Hydrochlorothiazide Tablets

Biochem/physiol Actions

Carbonic anhydrase inhibitor

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H351

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 6

1 of 6

Hydrochlorothiazide solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

H-001

Hydrochlorothiazide solution

Benzothiadiazine Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1192

Benzothiadiazine Related Compound A

Bisoprolol fumarate United States Pharmacopeia (USP) Reference Standard

USP

1075757

Bisoprolol fumarate

4-Amino-6-chloro-1,3-benzenedisulfonamide 98%

Sigma-Aldrich

308560

4-Amino-6-chloro-1,3-benzenedisulfonamide

Chlorothiazide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1179

Chlorothiazide

Amlodipine besylate United States Pharmacopeia (USP) Reference Standard

USP

1029501

Amlodipine besylate

Captopril and Hydrochlorothiazide Tablets
United States Pharmacopeia, 43(4), 737-737 (2019)
Soham Rej et al.
Drugs & aging, 31(12), 911-916 (2014-10-22)
Little is known about how lithium should be dosed to achieve therapeutic but safe serum concentrations in older adults. In this paper, we investigate how the lithium dose-concentration ratio changes across the lifespan. This was a cross-sectional analysis of 63
Dragos Vinereanu et al.
American heart journal, 168(4), 446-456 (2014-09-30)
The objective of this study is to compare the effects of 2 types of diuretics, indapamide and hydrochlorothiazide, added to an angiotensin-converting enzyme inhibitor, on ventricular and arterial functions in patients with hypertension and diabetes. This is a prospective, randomized
Sverre E Kjeldsen et al.
Journal of clinical hypertension (Greenwich, Conn.), 15(6), 380-388 (2013-06-05)
Older patients frequently receive angiotensin II receptor blocker/diuretic combinations to control blood pressure (BP), although there have been relatively few trials specifically examining this patient population. A pooled analysis was performed of data from 7 randomized trials of telmisartan/hydrochlorothiazide combinations
Edgar V Lerma
Current hypertension reports, 13(5), 386-395 (2011-07-29)
Hypertension remains an important problem that increases the risk of cardiovascular disease and is a leading cause of mortality worldwide. Achieving long-term control of arterial hypertension, which has an estimated prevalence of 28% in the US adult population, would translate
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service