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USP

Lopinavir

United States Pharmacopeia (USP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C37H48N4O5
CAS Number:
192725-17-0
Molecular Weight:
628.80
UNSPSC Code:
41116107
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP/NF

API family

lopinavir

form

powder

packaging

pkg of 350 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white to off-white

mp

255.2-260.6 °F (124—127°C)

solubility

chloroform: soluble
isopropanol: soluble
methanol: freely soluble
methylene chloride: freely soluble
water: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

InChI key

KJHKTHWMRKYKJE-SUGCFTRWSA-N

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Related Categories

General description

Lopinavir is an antiretroviral agent and a protease inhibitor indicated for the management of human immunodeficiency virus (HIV) infection. It is a key component of Kaletra, the co-formulation of lopinavir and ritonavir.

Application

Lopinavir may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography techniques.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chloroquine phosphate United States Pharmacopeia (USP) Reference Standard

USP

1118000

Chloroquine phosphate

Arbidol hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0860

Arbidol hydrochloride

Darunavir ≥98% (HPLC)

Sigma-Aldrich

SML0937

Darunavir

vibrant-m

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Lopinavir USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 37(6), 2610-2610 (2020)
Determination of 19 antiretroviral agents in pharmaceuticals or suspected products with two methods using high-performance liquid chromatography
Rebiere H, et al.
Journal of Chromatography. B, Biomedical Applications, 850(1-2), 376-383 (2007)
Therapeutic drug monitoring of lopinavir/ritonavir in pregnancy
Lambert JS, et al.
HIV Medicine, 12(3), 166-173 (2011)

Related Content

Lopinavir and Ritonavir Tablets Assay Method Following United States Pharmacopeia Monograph Guidelines Using an Ascentis C8 Column and UV Detection

This application note illustrates how it is possible to set-up an assay method for Lopinavir and Ritonavir tablets.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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