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33114

Sigma-Aldrich

Citric acid monohydrate

puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., buffer substance, 99.5-102%

Synonym(s):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS Number:
5949-29-1
Molecular Weight:
210.14
Beilstein/REAXYS Number:
4018641
EC Number:
201-069-1
MDL number:
MFCD00149972
UNSPSC Code:
12352100
PubChem Substance ID:
57648756
NACRES:
NA.21

grade

ACS reagent
puriss. p.a.

Quality Level

200

agency

USP/NF
reag. ISO
reag. Ph. Eur.

assay

99.5-100.5% (calc. on anhydrous substance)
99.5-102%

form

solid

impurities

≤0.005% insolubles in water
≤2 ppm heavy metals (as Pb)
7.5-9.0% water (Karl Fischer)

ign. residue

≤0.01% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl-): ≤5 mg/kg
oxalate (C2O42-): ≤50 ppm
phosphate (PO43-): ≤10 mg/kg
sulfate (SO42-): ≤20 ppm

cation traces

Ca: ≤50 mg/kg
Cu: ≤5 mg/kg
Fe: ≤3 ppm
Pb: ≤2 ppm
Zn: ≤5 mg/kg

suitability

complies for appearance of solution
complies for reaction against H2SO4

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

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General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1.

Application

Citric acid monohydrate may be used in the preparation of tris-citrate buffer and Otto I isolation buffer used in bioprotocols. It may also be used to improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 1

flash_point_f

345.0 °F

flash_point_c

173.9 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBK6967
STBK4084
STBK2947
STBK1425
STBK0582

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Determination of the Developmental Origin of Seeds Containing Endosperm Using Flow Cytometric Analysis
Sailer C, et al.
PLoS Genetics, 5(11) (2015)
Citric acid monohydrate as a release-modifying agent in melt extruded matrix tablets.
Schilling SU, et al.
International Journal of Pharmaceutics, 361(1), 158-168 (2008)
Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics.
R K Selander et al.
Applied and environmental microbiology, 51(5), 873-884 (1986-05-01)
S Massberg et al.
The Journal of experimental medicine, 189(8), 1255-1264 (1999-04-20)
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and stroke. Platelet adhesion and aggregation during ischemia-reperfusion are thought to be the initial steps leading to remodeling and reocclusion of the postischemic vasculature.
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
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