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C7129

Sigma-Aldrich

Citric acid monohydrate

reagent grade, ≥98% (GC/titration)

Synonym(s):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS Number:
5949-29-1
Molecular Weight:
210.14
Beilstein/REAXYS Number:
4018641
EC Number:
201-069-1
MDL number:
MFCD00149972
UNSPSC Code:
12352100
PubChem Substance ID:
24892935
NACRES:
NA.21

grade

reagent grade

Quality Level

300

assay

≥98% (GC/titration)

form

powder

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

solubility

H2O: 100 mg/mL, clear, colorless (Turbidity)

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

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General description

Citric acid monohydrate(CAM) is an organic acid. It can be produced by crystallization from mother liquor of citric acid solution at 20-25°C during citric acid synthesis. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061±123)Jmol-1. An investigation of its crystal growth kinetics indicates that growth is linearly dependent on size.

Application

Citric acid monohydrate may be used:
  • To prepare citric acid solution employed in the acetone method of 68Ga pre-purification and radiolabeling technique.
  • To prepare Tris-citrate buffer employed for the electrophoresis of bacterial enzymes.
  • To improve the release of diltiazem hydrochloride from melt extruded matrix tablets.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 1

flash_point_f

345.0 °F

flash_point_c

173.9 °C

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Size dependency of citric acid monohydrate growth kinetics.
Bravi M and Mazzarotta B.
Chemical Engineering Journal, 70(3), 203-207 (1998)
Methods of multilocus enzyme electrophoresis for bacterial population genetics and systematics.
R K Selander et al.
Applied and environmental microbiology, 51(5), 873-884 (1986-05-01)
Michael K Schultz et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 76, 46-54 (2012-10-03)
A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages
New perspectives for citric acid production and application.
Soccol CR, et al.
Food Technology and Biotechnology, 44(2), 141-149 (2006)
Sandra U Schilling et al.
International journal of pharmaceutics, 361(1-2), 158-168 (2008-06-28)
Incomplete drug release and particle size-dependent dissolution performance can compromise the quality of controlled release matrix systems. The objective of the current study was to investigate the ability of citric acid monohydrate (CA MH) to enhance the release of diltiazem
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